Selenium
Retrosynthesis
Describe a target molecule and get ranked synthesis strategies — each broken into concrete steps with predicted yields.
Stage Planning Stage
AI-Powered Chemical Synthesis
AI that designs, optimizes, and runs chemical reactions.
Accelerating pharma R&D from years to months.
You design the molecules,
we make them.
Any molecule.
How it works
Selenium · Retrosynthesis
Palladium · Plate Design
Cobalt · Execution
Analysis · LC-MS Report
01
Plan
Design synthesis routes with AI
02
Optimize
Screen conditions at scale
03
Execute
Run reactions in any lab
04
Discover
Analyze results, iterate faster
Planning
Design your synthesis, then optimize it
Two AI tools that take you from target molecule to optimized conditions.
Palladium
Condition Optimization
Pick a reaction and screen catalysts, ligands, bases, and solvents in a single plate. AI designs the layout so every well counts.
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2
3
4
5
6
A
B
C
D
LIGAND
BrettPhos6
(tBu)PhCPhos4
tBuXPhos2
AlPhos2
RuPhos2
SPhos2
tBuBrettPhos2
P(tBu)₃2
Josiphos CyPFtBu2
BASE
NaOtBu11
LiHMDS11
Cs₂CO₃1
K₃PO₄1
SOLVENT
toluene8
CPME6
2-MeTHF6
1,4-dioxane4
99% yield on first plate
>80% conversion rate
Execution
Your lab or ours
Run it yourself with Cobalt, or let us handle the chemistry.
Run it in your lab
Translate your optimized conditions into execution-ready protocols for Chemspeed, Opentrons, or any automation platform. No coding required.
Try CobaltWe run it for you
Submit your optimized conditions. We handle plate execution and deliver results. From screening plates to gram-scale synthesis.
$8,000 starting, without substrates
Request a Quote Benefits
Made for your lab, powered by AI
Fast Learning Curve
Master lab automation in hours, not weeks.
Scale Experiments Easily
Run diverse workflows with the same equipment.
Reliable Results
Reduce errors and improve reproducibility.
Focus on Science
Agents handle the technicalities; you make the discovery.
FAQ
Frequently asked questions.
What kinds of molecules can b12 handle?
We specialize in complex molecules that go beyond standard library synthesis, including multi-step targets, novel scaffolds, and compounds with challenging selectivity requirements.
How is b12 different from library synthesis providers?
Library synthesis services handle simple, well-known transformations. b12 combines AI-driven retrosynthesis planning with expert execution to tackle harder, multi-step routes that library providers cannot.
Can I use the platform without ordering synthesis services?
Yes. Selenium, Palladium, and Cobalt are all available as self-serve software tools at app.b12-labs.com. Use them for retrosynthesis planning, plate design, and lab automation whether or not you order synthesis.
How much does plate design and execution cost?
Plate design and execution starts at $8,000 USD without substrates. Full molecular synthesis is quoted per project based on complexity. Contact us for a detailed estimate.
Is coding required?
No. All three tools are designed so scientists can describe intent in natural language. The AI handles protocol generation, plate layout, and workflow structure.
How long does it take to get started?
You can start using the platform immediately at app.b12-labs.com. For synthesis services, typical turnaround depends on molecular complexity. We provide a timeline with your quote.
From the blog
Join pharma and biotech teams using AI for synthesis
Built by researchers from Roche, Chemspeed, Max Planck Institute, and EPFL