Tackle Complex Molecules
Go beyond library synthesis. Plan and execute routes for targets that standard tools cannot handle.
Backed by Y Combinator
AI-Powered
AI-Powered
Chemical Synthesis
Plan complex synthesis routes, design optimized experiments, and automate lab workflows – or let us synthesize molecules for you.
AI Chemical Synthesis Retrosynthesis Planning Experiment Optimization Lab Automation Complex Molecule Specialists Software + Services AI Chemical Synthesis Retrosynthesis Planning Experiment Optimization Lab Automation Complex Molecule Specialists Software + Services AI Chemical Synthesis Retrosynthesis Planning Experiment Optimization Lab Automation Complex Molecule Specialists Software + Services AI Chemical Synthesis Retrosynthesis Planning Experiment Optimization Lab Automation Complex Molecule Specialists Software + Services
Benefits
From planning to execution
Accelerate Discovery
Cut synthesis planning from days to minutes. Screen conditions faster with AI-designed experiments.
Software or Service
Use our platform yourself, or let us do the synthesis. Flexible engagement from self-serve to full-service.
Reliable, Reproducible Results
AI-generated protocols are transparent and reviewable. No opaque black boxes, no fragile handoffs.
The Platform
Three tools for every stage of synthesis
Selenium
Synthesis ExpertInput a target molecule and get actionable retrosynthesis plans in minutes, not days. Built for the complex molecules that library synthesis cannot reach.
For medicinal chemists and synthesis planners
Cobalt
Automation CopilotTranslate natural language into execution-ready workflows for instruments like Chemspeed, without specialized programming.
For automation scientists and lab engineers
Experiment Design
Palladium
Plate DesignerDescribe your optimization goal in plain language. Get high-value plate layouts that surface winning conditions earlier in the campaign.
For process chemists and HTE teams
Select the best conditions for this challenging Buchwald-Hartwig amination
1
2
3
4
5
6
A
B
C
D
LIGAND
BrettPhos6
L7 / (tBu)PhCPhos4
tBuXPhos2
AlPhos2
RuPhos2
SPhos2
tBuBrettPhos2
P(tBu)₃2
Josiphos CyPFtBu2
BASE
NaOtBu11
LiHMDS11
Cs₂CO₃1
K₃PO₄1
SOLVENT
toluene8
CPME6
2-MeTHF6
1,4-dioxane4
Services
We make the molecules for you.
No lab? No problem. We handle the chemistry.
Plate Design & Execution
We design optimized screening plates for your reaction and execute them in our labs. Conditions screening, hit identification, and data delivery.
$8,000 starting, without substrates
Learn More Full Molecular Synthesis
Need molecules made, not just planned? We synthesize complex targets that go beyond standard library chemistry, from milligrams to grams.
Custom quote based on molecular complexity
Request a Quote 
FAQ
Frequently asked questions.
What kinds of molecules can b12 handle?
We specialize in complex molecules that go beyond standard library synthesis, including multi-step targets, novel scaffolds, and compounds with challenging selectivity requirements.
How is b12 different from library synthesis providers?
Library synthesis services handle simple, well-known transformations. b12 combines AI-driven retrosynthesis planning with expert execution to tackle harder, multi-step routes that library providers cannot.
Can I use the platform without ordering synthesis services?
Yes. Selenium, Palladium, and Cobalt are all available as self-serve software tools at app.b12-labs.com. Use them for retrosynthesis planning, plate design, and lab automation whether or not you order synthesis.
How much does plate design and execution cost?
Plate design and execution starts at $8,000 USD without substrates. Full molecular synthesis is quoted per project based on complexity. Contact us for a detailed estimate.
Is coding required?
No. All three tools are designed so scientists can describe intent in natural language. The AI handles protocol generation, plate layout, and workflow structure.
How long does it take to get started?
You can start using the platform immediately at app.b12-labs.com. For synthesis services, typical turnaround depends on molecular complexity. We provide a timeline with your quote.